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Effects of OTC Ibuprofen vs. Celecoxib on Upper GI Injury

David J. Bjorkman, Msph, Sm

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Abstract

Selective cyclooxygenase (COX)-2 inhibitors are associated with fewer gastrointestinal complications and endoscopic lesions than are prescription-strength nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). However, few studies have compared over-the-counter (OTC) doses of nonselective NSAIDs with coxibs. In this two-phase, randomized, placebo-controlled, double-blind crossover study, researchers randomly assigned 93 patients to 10-day courses of ibuprofen (1200 mg/day) followed by celecoxib (200 mg/day), celecoxib followed by ibuprofen, naproxen …

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What this paper is about

Selective cyclooxygenase (COX)-2 inhibitors are associated with fewer gastrointestinal complications and endoscopic lesions than are prescription-strength nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). However, few studies have compared over-the-counter (OTC) doses of nonselective NSAIDs with coxibs. In this two-phase, randomized, placebo-controlled, double-blind crossover study, researchers randomly assigned 93 patients to 10-day courses of ibuprofen (1200 mg/day) followed by celecoxib (200 mg/day), celecoxib followed by ibuprofen, naproxen …

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Available abstract

Selective cyclooxygenase (COX)-2 inhibitors are associated with fewer gastrointestinal complications and endoscopic lesions than are prescription-strength nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). However, few studies have compared over-the-counter (OTC) doses of nonselective NSAIDs with coxibs. In this two-phase, randomized, placebo-controlled, double-blind crossover study, researchers randomly assigned 93 patients to 10-day courses of ibuprofen (1200 mg/day) followed by celecoxib (200 mg/day), celecoxib followed by ibuprofen, naproxen …

Key concepts: Celecoxib, Medicine, Ibuprofen, Naproxen, Nonsteroidal, Placebo, Cyclooxygenase, Rofecoxib

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