ScholarLens Back to search
1998•Indian Journal of PharmacologyRequires access

CALCIUM DEPENDENCY OF THE POSITIVE INOTROPIC EFFECTS OF PHOSPHODIESTERASE INHIBITORS ON THE AMPHIBIAN AND MAMMALIAN MYOCARDIUM

Archana R. Juvekar, R. V. S. V. Vadlamudi

Open publisher page 1 citations

Abstract

Objective: To study the relationship of changing Ca2 + levels, to the inotropic responses of amphibian and mammalian myocardium, to phosphodiesterase (PDE) Ill inhibitors, milrinone and trequinsin hydrochloride (HL725). Methods: The inotropic effects of milrinone and HL725 were investigated, on the isolated perfused frog heart and the isolated electrically - paced guinea pig left atrium at different perfusate calcium levels. Results: HL725 and milrinone produced a dose-dependent positive inotropy effect. The mammalian myocardium exhibited greater magnitude of positive inotropic response as compared to the isolated frog heart. Conclusion: The responses to HL725 and milrinone are species specific; due to the inherent ultrastructural variations and the resultant changed intracellular Ca 2+ mrleu.

About this research paper

What this paper is about

Objective: To study the relationship of changing Ca2 + levels, to the inotropic responses of amphibian and mammalian myocardium, to phosphodiesterase (PDE) Ill inhibitors, milrinone and trequinsin hydrochloride (HL725). Methods: The inotropic effects of milrinone and HL725 were investigated, on the isolated perfused frog heart and the isolated electrically - paced guinea pig left atrium at different perfusate calcium levels. Results: HL725 and milrinone produced a dose-dependent positive inotropy effect. The mammalian myocardium exhibited greater magnitude of positive inotropic response as compared to the isolated frog heart. Conclusion: The responses to HL725 and milrinone are species specific; due to the inherent ultrastructural variations and the resultant changed intracellular Ca 2+ mrleu.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To study the relationship of changing Ca2 + levels, to the inotropic responses of amphibian and mammalian myocardium, to phosphodiesterase (PDE) Ill inhibitors, milrinone and trequinsin hydrochloride (HL725). Methods: The inotropic effects of milrinone and HL725 were investigated, on the isolated perfused frog heart and the isolated electrically - paced guinea pig left atrium at different perfusate calcium levels. Results: HL725 and milrinone produced a dose-dependent positive inotropy effect. The mammalian myocardium exhibited greater magnitude of positive inotropic response as compared to the isolated frog heart. Conclusion: The responses to HL725 and milrinone are species specific; due to the inherent ultrastructural variations and the resultant changed intracellular Ca 2+ mrleu.

Key concepts: Milrinone, Inotrope, Calcium, Phosphodiesterase, Intracellular, Internal medicine, Guinea pig, Calcium in biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
CALCIUM DEPENDENCY OF THE POSITIVE INOTROPIC EFFECTS OF PHOSPHODIESTERASE INHIBITORS ON THE AMPHIBIAN AND MAMMALIAN MYOCARDIUM — Research Paper | ScholarLens