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[Milrinone decreases the positive inotropic response of heart muscle to izadrin].

Bardamova Ib, Afanas'ev Sa

Abstract

The interaction of the cAMP-phosphodiesterase inhibitor milrinone and the beta-adrenoceptor agonist isoproterenol was studied on guinea-pig isolated hearts. Milrinone, (10 microns) caused a positive inotropic response which differed from that of isoproterenol (7 nM) and decreased cardiac inotropic responses to the subsequent administration of isadrin despite a significant great rise in cAMP. The interaction of the drugs is assumed to be associated with the milrinone-induced increase in cGMP which is able to restrict myocardial cAMP-activated processes.

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Key concepts: Milrinone, Inotrope, Phosphodiesterase inhibitor, Internal medicine, Phosphodiesterase, Enoximone, Medicine, Agonist