ScholarLens Back to search
2006•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access

Study of Preventive and Therapeutic Effects of Large Dose Vitamin C on Acute Lung Injury

Dexin Zhang, Xiuzhen Sun, Yun Liu

Open publisher page 0 citations

Abstract

[Objective] To investigate the preventive and therapeutic effect of large dose vitamin C on the acute lung injury model of rabbits induced by oleic acid. [Methods] A total of 30 rabbits were divided into four group randomly: control group (CG); oleic acid group (OG); preventive group (PG); treatment group (TG). Oxygen pressure in arterial blood (PaO2), superoxide dismutase (SOD) and malondialdehyde (MDA) in blood were measured in 0, 30, 90, 150 min respectively. All the animals were killed in 150 min later. Total protein in broncho-alveolar lavage fluid (BALF) and lung wet-dry weight ratio of the right lung was measured and the left lung sample was treated by formaldehyde and for pathological test. [Results] PaO2, SOD in PG group and TG group were significantly higher than that of OG group (P＜0.01) and MDA significantly decreased (P＜0.01) 30min later after injected oleic acid; BALF and lung wet-dry weight ratio in PG group and TG group significantly decreased (P＜0.05) than that of OG group; HE staining showed that the lung injury in PG group and TG group was improved. [Conclusions] A large dose vitamin C (500mg/kg) has preventive effect on acute lung injury.

About this research paper

What this paper is about

[Objective] To investigate the preventive and therapeutic effect of large dose vitamin C on the acute lung injury model of rabbits induced by oleic acid. [Methods] A total of 30 rabbits were divided into four group randomly: control group (CG); oleic acid group (OG); preventive group (PG); treatment group (TG). Oxygen pressure in arterial blood (PaO2), superoxide dismutase (SOD) and malondialdehyde (MDA) in blood were measured in 0, 30, 90, 150 min respectively. All the animals were killed in 150 min later. Total protein in broncho-alveolar lavage fluid (BALF) and lung wet-dry weight ratio of the right lung was measured and the left lung sample was treated by formaldehyde and for pathological test. [Results] PaO2, SOD in PG group and TG group were significantly higher than that of OG group (P＜0.01) and MDA significantly decreased (P＜0.01) 30min later after injected oleic acid; BALF and lung wet-dry weight ratio in PG group and TG group significantly decreased (P＜0.05) than that of OG group; HE staining showed that the lung injury in PG group and TG group was improved. [Conclusions] A large dose vitamin C (500mg/kg) has preventive effect on acute lung injury.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

[Objective] To investigate the preventive and therapeutic effect of large dose vitamin C on the acute lung injury model of rabbits induced by oleic acid. [Methods] A total of 30 rabbits were divided into four group randomly: control group (CG); oleic acid group (OG); preventive group (PG); treatment group (TG). Oxygen pressure in arterial blood (PaO2), superoxide dismutase (SOD) and malondialdehyde (MDA) in blood were measured in 0, 30, 90, 150 min respectively. All the animals were killed in 150 min later. Total protein in broncho-alveolar lavage fluid (BALF) and lung wet-dry weight ratio of the right lung was measured and the left lung sample was treated by formaldehyde and for pathological test. [Results] PaO2, SOD in PG group and TG group were significantly higher than that of OG group (P＜0.01) and MDA significantly decreased (P＜0.01) 30min later after injected oleic acid; BALF and lung wet-dry weight ratio in PG group and TG group significantly decreased (P＜0.05) than that of OG group; HE staining showed that the lung injury in PG group and TG group was improved. [Conclusions] A large dose vitamin C (500mg/kg) has preventive effect on acute lung injury.

Key concepts: Malondialdehyde, Lung, Medicine, Vitamin C, Superoxide dismutase, Oleic acid, Internal medicine, Gastroenterology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Study of Preventive and Therapeutic Effects of Large Dose Vitamin C on Acute Lung Injury — Research Paper | ScholarLens