Expression of Aromatase Protein in Endometrial Diseases

[Objective] To investigate the expressions of aromatase protein, estrogen receptor (ER), progesterone receptor (PR) and nucleus related antigen (Ki67) in endometrial diseases, and to evaluate their clinical significances in early diagnosis and endocrine therapy of endometrial adenocarcinoma. [Methods] Experimental group: 148 cases including 30 of endometrial hyperplasia, 30 of atypical proliferation and 88 of endometrial adenocarcinoma. Control group: 60 cases including 30 of proliferative endometrium and 30 of secretory endometrium. Immunohistochemical technology method was used to detect the expressions of Aromatase, ER, PR and Ki67 in these cases. [Results] The expressions of Aromatase protein, ER, PR and Ki67 in endometrial proliferation, atypical proliferation had no statistical significances compared with the proliferative endometrium (P＞0.05). The expression of Aromatase protein in endometrial adenocarcinoma increased obviously, which is higher than benign diseases and control group prominently with statistical significances (P＜0.01). However, the positive rate of Aromatase protein did not increase with the increasing of clinical phase and grade of cellular differentiation as well as lymphatic metastasis. The decreased positive expressions of ER, PR and increased positive expression of Ki67 in endometrial adenocarcinoma showed a statistical significance compared with control group. What is more, Aromatase did not correlate with ER, PR and Ki67 in endometrial adenocarcinoma. [Conclusion] Aromatase protein is related to the incidence of endometrial adenocarcinoma, and the expressions of antigens (Aromatase, ER, PR and Ki67) provide academic evidences for early diagnosis and endocrine therapy of endometrial adenocarcinoma.