2016•RSC AdvancesRequires access

Cervicare™ induces apoptosis in HeLa and CaSki cells through ROS production and loss of mitochondrial membrane potential

Neda Amini, Fadzilah Adibah Abdul Majid, Mohsen Marvibaigi, Eko Supriyanto, Saravana Kumar Jaganathan, Wong Tet Soon, Rozita Nasiri, Javad Hamzehalipour

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Abstract

The effect of the ethanol and aqueous extracts of Cervicare™, a poly-herbal preparation comprised of the combination of 6 plants, on cell proliferation and apoptosis using cervical cancer HeLa and CaSki cells was investigated for the first time in the present study.

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Key concepts: HeLa, Apoptosis, Chemistry, Cervical carcinoma, Mitochondrion, Cell biology, Inner mitochondrial membrane, Cell