2014•Asian Journal of Research in ChemistryRequires access

First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Amlodipine Besylate and Indapamide in Combined Pharmaceutical Dosage Form

Meghna P. Patel, R Hasumati, Nehal Shah

Abstract

A simple, accurate, precise, rapid, economical UV spectrophotometry method namely first order derivative spectrophotometry have been developed and validated for estimation of Indapamide (IND) and Amlodipine besylate (AML) in combined tablet dosage form and can be used in routine analysis. In this method, the absorbance at 237.4 nm (ZCP of AML) and 241 nm (ZCP of IND) were used for estimation of IND and AML respectively. The method was found to be linear in the concentration range of 1.5–9 μg/ml for IND (r2=0.99983) and 5–30 μg/ml for AML (r2=0.99966). Mean assay was found to be 99.72% and 100.28% for IND and AML respectively.

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Key concepts: Indapamide, Amlodipine, Dosage form, Chromatography, Spectrophotometry, Absorbance, Derivative (finance), Chemistry