2011•Research Journal of Pharmacy and TechnologyRequires access

Simultaneous Estimation of Telmisartan and Amlodipine in Tablet Dosage Form by RP-HPLC

Shankar Kanchana, Ajithadas Aruna, V. Niraimathi, A. Jerad Suresh

Abstract

A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of telmisartan and amlodipine in tablet formulation. The separation was achieved by Luna C18 column and phosphate buffer pH 3.0 and acetonitrile (60:40v/v) as mobile phase, at a flow rate of 1.0mL/min. Detection was carried out at 251 nm. Retention time of telmisartan and amlodipine was found to be 4.427min and 2.643min respectively. The method has been validated for linearity, accuracy and precision. Linearity for telmisartan and amlodipine were in the range of 160–240μg/mL and 25–45μg/mL, respectively. The mean recoveries obtained for telmisartan and amlodipine were 102.4% and 101.6% respectively. Developed method was found to be accurate, precise, selective and rapid for simultaneous estimation of telmisartan and amlodipine in tablet dosage form.

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Key concepts: Telmisartan, Amlodipine, Chromatography, Dosage form, Phosphate buffered saline, Chemistry, Retention time, Materials science