Hepatoprotective effects of phenolic acid from Salvia chinensis Benth. on CCl4 induced acute liver injury in mice.

[Objective] This research was to study the protective effects of phenolic acid from Salvia chinensis Benth.(PAS) against CCL4-induced acute liver injury in mice and its possible mechanism.[Method] Mice were divided into control group,model group randomly,S.chinensis was divided into 6 groups such as high,medium and low-dose treatment group and positive group(Silibinin).Mice were pretreated by phenolic acid(i.g) for 5 d.Hepatic injury was induced by injecting 1 ml/kg 50% peanut oil solution of carbon tetrachloride,the contents of AST,ALT,T-AOC,MDA,GSH were determined after 24.[Result] Compared with model group,serum AST,ALT in PAS high,medium and low-dose groups reduced significantly;total antioxidant capacity(T-AOC),reduced gluthione(GSH) increased,as well as MDA content decreased significantly,all above indexes changed in a dose-dependent way.Histopathological study showed that the protective effects of the PSA also indicated a dose-dependent manner.[Conclusion] The PAS has a protective effect on the carbon tetrachloride induced acute liver injury in mice,hepatoprotective effects of PAS may be related to its antioxidant characteristic.Total phenolic acids of S.chinensis can enhance anti-oxidant capacity of organizations,reduce carbon tetrachloride induced lipid peroxidation,and protect cell membranes from damage.