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2005•Indian Journal of Pharmaceutical SciencesRequires access

Stability Indicating RP-HPLC Method For Determination Of Pioglitazone From Tablets

D. B Wanjari, Naresh J. Gaikwad

Open publisher page 9 citations

Abstract

A stability indicating simple, rapid and precise reversed-phase HPLC method has been developed for the quantitation of pioglitazone in tablet on a Hypersil C-8 (250x4.6 mm) column using a mobile phase consisting acetonitrile:0.15% v/v triethylamine (40:60 v/v) adjusted to pH 4.6 with orthophosphoric acid at a flow rate of 1.5 ml/min and detection at 220 nm. The retention time of pioglitazone have been found to be 7.6 min and recoveries were between 99-101%. Validation of the proposed method also been done.

About this research paper

What this paper is about

A stability indicating simple, rapid and precise reversed-phase HPLC method has been developed for the quantitation of pioglitazone in tablet on a Hypersil C-8 (250x4.6 mm) column using a mobile phase consisting acetonitrile:0.15% v/v triethylamine (40:60 v/v) adjusted to pH 4.6 with orthophosphoric acid at a flow rate of 1.5 ml/min and detection at 220 nm. The retention time of pioglitazone have been found to be 7.6 min and recoveries were between 99-101%. Validation of the proposed method also been done.

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OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A stability indicating simple, rapid and precise reversed-phase HPLC method has been developed for the quantitation of pioglitazone in tablet on a Hypersil C-8 (250x4.6 mm) column using a mobile phase consisting acetonitrile:0.15% v/v triethylamine (40:60 v/v) adjusted to pH 4.6 with orthophosphoric acid at a flow rate of 1.5 ml/min and detection at 220 nm. The retention time of pioglitazone have been found to be 7.6 min and recoveries were between 99-101%. Validation of the proposed method also been done.

Key concepts: Pioglitazone, Triethylamine, Chromatography, High-performance liquid chromatography, Chemistry, Acetonitrile, Retention time, Medicine

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