2002•PubMedRequires access

Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.

P Kontoleon, Ιoannis Ilias, D. A. Koutras, Dimitris Kontogiannis, P. D. Papapetrou

Abstract

We report the case of a 27-year-old woman with hyperthyroidism during pregnancy. Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ). The remaining pregnancy, delivery and follow-up period were uneventful for the mother and her offspring. Antithyroid treatment during pregnancy should allow the use not only of PTU but also of CBZ and methimazole.

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Key concepts: Carbimazole, Propylthiouracil, Medicine, Pregnancy, Antithyroid agent, Methimazole, Internal medicine, Offspring