ScholarLens Back to search
1967•EndocrinologyRequires access

Effect of Propylthiouracil and Methimazole on the Oxygen Consumption of Hypothyroid Rats Receiving Thyroxine or Triiodothyronim?

George A. Bray, STEPHEN HILDRETH

Open publisher page 9 citations

Abstract

The calorigenic response to thyroxine and triiodothyronine has been compared in hypothyroid rats treated with either propylthiouracil or methimazole. Propylthiouracil reduced the calorigenic response to thyroxine, but methimazole did not. Neither methimazole nor propylthiouracil diminished the calorigenic response to triiodothyronine, and methimazole may even have increased this response when 80μg/day of triiodothyronine was administered. When methimazole was replaced by propylthiouracil in the diet of rats treated with thyroxine, the oxygen consumption fell slowly over a period of 2 weeks, but there was little rise in oxygen consumption during the 2 weeks after the diet was changed from propylthiouracil to methimazole. (Endocrinology81: 1018, 1967)

About this research paper

What this paper is about

The calorigenic response to thyroxine and triiodothyronine has been compared in hypothyroid rats treated with either propylthiouracil or methimazole. Propylthiouracil reduced the calorigenic response to thyroxine, but methimazole did not. Neither methimazole nor propylthiouracil diminished the calorigenic response to triiodothyronine, and methimazole may even have increased this response when 80μg/day of triiodothyronine was administered. When methimazole was replaced by propylthiouracil in the diet of rats treated with thyroxine, the oxygen consumption fell slowly over a period of 2 weeks, but there was little rise in oxygen consumption during the 2 weeks after the diet was changed from propylthiouracil to methimazole. (Endocrinology81: 1018, 1967)

Why it matters

OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The calorigenic response to thyroxine and triiodothyronine has been compared in hypothyroid rats treated with either propylthiouracil or methimazole. Propylthiouracil reduced the calorigenic response to thyroxine, but methimazole did not. Neither methimazole nor propylthiouracil diminished the calorigenic response to triiodothyronine, and methimazole may even have increased this response when 80μg/day of triiodothyronine was administered. When methimazole was replaced by propylthiouracil in the diet of rats treated with thyroxine, the oxygen consumption fell slowly over a period of 2 weeks, but there was little rise in oxygen consumption during the 2 weeks after the diet was changed from propylthiouracil to methimazole. (Endocrinology81: 1018, 1967)

Key concepts: Propylthiouracil, Methimazole, Internal medicine, Endocrinology, Triiodothyronine, Antithyroid agent, Endogeny, Chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of Propylthiouracil and Methimazole on the Oxygen Consumption of Hypothyroid Rats Receiving Thyroxine or Triiodothyronim? — Research Paper | ScholarLens