Clinical significance of the change of serum cholinesterase in the MODS patients

Objective　To observe the trend of serum cholinesterase change in the MODS patients，discuss the relationgship between the level of the serum cholinesterase and the severity of MODS patients，also evaluate the value of serum cholinesterase level while judging the prognosis of MODS. Methods　All the observe subjects were selected from the admission patients of the EICU of Tianjin medical university general hospital. 92 MODS patients aged 22～92 years were included while 30 non-MODS patients aged 20～87 years included as control group. Detect the serum cholinesterase level respectively at admission and in the 24 th hour of admission. Calculate the value change of serum cholinesterase. The MODS patients were divided into two groups based on their prognosis：survival group and death group. Results　Compared with the control group，the MODS patients had a decreased level of serum cholinesterase which had a statistic significance(P<0.05). The serum cholinesterase level of the MODS which dead in day 28 was decreased persistently as comparing with the survival group. Using multinomial Logistic regression analysis，the change value of serum cholinesterase level，APACHEⅡ scores and the number of dysfunction organ were independent risk factors for judging the prognosis in the MODS patients. Conclusions　The serum cholinesterase level at admission，in the 24 th hour of admission and the change value of serum cholinesterase level have a close ralationship with the severity of MODS. And the change value of serum cholinesterase is an independent risk factor for judging the prognosis in the MODS patients.