1986•PubMedRequires access
On the cross-coupling reaction of 1,3-dimethylthymine and thymidine epoxides with nucleophiles.
T. HARAYAMA, Reiko Yanada, K. IIO, Fumio Yoneda
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Abstract
Solvent effect in reaction of 1,3-dimethylthymine epoxide (1) with amines was investigated. The results are summarized in Table I, indicating that the ratio of formation of the cis product (2) increases as a solvent becomes more polar. Reaction of thymidine epoxide (5) with nucleophiles was also examined.