Comparison of Eradicating Helicobacter pylori Infection in Duodenal Ulcer Patients by Three short-term Triple Therapies

AIM: To observe the effect of eradicating Helicobacter pylon (Hp) and treating duodenal ulcer by 3 d and 5 d triple therapies through comparing with the 7 d triple therapy. METHODS: One hundred and sixteen patients who were confirmed in duodenal ulcer active period by gastroscopy and Hp positive confirmed by rapid urease test, serum anti-Hp antibody (ELASE) or histological examination were divided into three groups: 3 d group (n=39), 5 d group (n=37) and 7 d controlled group (n=40). All three groups were provided triple therapy first: rabeprazole 10 mg+furazolidone 100mg+clarithromycin 250 mg, bid, for 3, 5, and 7 d, respectively. Then rabeprazole 10 mg was provided once a day. The period of 3, 5 and 7 d group was 25, 23, and 21 d, respectively. Twenty- eight day to 56 d after taking the medicine, 13C urea breath test was performed to judge the effect of Hp eradication rate. In d 1, 2, 3, 7, 21, 35, the symptoms of patients such as epigastralgia, burning pain and acidity were evaluated simultaneously. RESULTS: One hundred and seven patients accomplished all therapy scheme, 9 patients lost. There are 37, 35 and 35 patients in 3, 5, 7 d group accomplished therapy, respectively. The examination results indicated that the Hp eradication rate of each group was as follows: 3 d group was 76 % (28/37), 5dgroupwas89 % (31/35), 7dgroup was 91% (32/35). There was no significant difference be- comparison with non-metronidazole containing 7 d triple therapy, in order to observe Hp eradication and effect and symptom improvement to duodenal ulcer by 3 d and 5 d triple therapies.