1959•OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)Requires access
EFFECT OF RADIATIONS ON THE NUCLEIC ACID METABOLISM IN MICE. III. COMPARISON OF X-RAY AND Co$sup 60$ GAMMA-RAY ON NUCLEIC ACID CONTENT OF THE THYMUS, SPLEEN AND TESTES
Goki Yamamoto
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Abstract
Male and female mice of C/sub 3/H strain were used. One group was irradiated by a single whole-body exposure of x rays (160 kvp) or Co/sup 60/ gamma rays of 50 r and 200 r under the same minute intensity. The other group was irradiated by x rays (150 kvp) 33.4 r in 3 min and 22 sec a day for 6 days, and gamma rays (Co/sup 60/ 33.4 r in 22 hours a day for 6 days. The total dose of both cases reached 200 r. After irradiation the nucleic acid metabolism and the amount of nucleic acid was measured. In single whole-bcdy irradiation of the same doses, x ray was more effective on nucleic acid metabolism in the spleen than Co/sup 60/ gamma -ray irradiation. The difference was exaggerated particularly in the case of 50 r exposure. However, no significant difference resulted in the thymus after x ray or Co/sup 60/irradiation. In a case of fractionated doses x ray also appeared more effective than Co/sup 60/ gamma ray. It was concluded that, as the dose rate was different in x ray and Co/sup 60/ irradiation, the time factor strongly influenced the effectiveness of irradiation. (Absts. Japan. Med., 1:more » No. 6, 1961)« less