2010•Journal of Shandong UniversityRequires access
Protective effect of Naoxintong on reperfusion after focal cerebral ischemia in rats.
Li-xin Qu, Su ShaoHua, Yang LiLing, Jialong Li, Xiaoyan Ren, Du Yifeng
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Abstract
Objective To investigate the protective effect of Naoxintong on reperfusion after focal cerebral ischemia in rats and explore effective methods to interfere with inflammation following acute cerebral ischemia-reperfusion injury.Methods Thirty male SD rats were randomly divided into three groups:the sham operation group(group A,n=10) ,the ischemic group (group B,n=10) ,and the Naoxintong group(group C,n=10) .Group B and C had focal cerebral ischemia-reperfusion produced by right middle cerebral artery occlusion.Activation of microglia,and expressions of CD68,IL-1β and TNF-α were detected by immunohistochemistry and Westernblot.Results Expressions of CD68,IL-1β and TNF-α were more markedly increased in group B than those in group A,and significantly lower in group C than those in group B.Conclusion Naoxintong can inhibit inflammation reaction after cerebral ischemia,which can provide an inhibitory effect on cerebral ischemia-reperfusion injury in rats.