A Clinical Study of ALA-PDT Reducing Recurrence of Condyloma Acuminatum on Male Urethra

Objective To explore whether 5-aminolevulinic acid photodymic therapy(ALA-PDT) can reduce the recurrence of condyloma acuminatum on male Urethra.Methods Seventy-three male patients of recurrent urethral condyloma aeuminatum were randomly divided into two groups. The warts of trial group were exorcized by ALA-PDT therapy,while CO2 laser was traditionally used to the controls,with a follow-up of 3 months to evaluate the therapeutic effect,recurrence rate and untoward reaction.Results The recovery rate after the 1st and the 2nd therapy were 65.12% and 83.72% respectively in the trial group,which was significantly higher than the control(40.00%,63.33%). Pain was the predominant intraoperative untoward reaction with the incidence rate of 48.84% in the trial group,higher than that in the control (13.33%). Meanwhile pain was the only postoperative untoward reaction in the trial group,which was statistically lower than the pain,swelling and infection in the control group (32.56% vs 60.00%).Conclusion ALA-PDT therapy can reduce the recurrence of condyloma acuminatum on male Urethra,with the advantage of higher cure rate,lesser pains and more convenient to the self care than the traditional therapy of CO2 laser.