Observation of the Therapeutic Effect of Photodynamic Therapy on Condyloma Acuminatum in Urethral Orifice

Objective To investigate the efficacy and safety of topical application of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) in the treatment of condyloma acuminatum in urethral orifice. Methods 90 patients with condyloma acuminatum in urethral orifice were divided into the experimental group and the control group at random following the sequence of coming for medical attention. The experimental group included 56 patients treated with photodynamic therapy,while in the control group,there were 34 patients treated with CO2 laser. The cases were followed up at regular visits for three months and and the cure rate and recurrence rate of the two groups were compared and whether a patient had any indisposition or showed any adverse reaction were observed.Results The cure rate was 92.86% for the ALA-PDT group and 52.94% for the control group. The recurrence rate for ALA-PDT group was 7.14% which was significantly lower than that in the control group (47.06%,P 0.01). There was a remarkable difference between two groups in cure rate and recurrence rate (P0.01). Moreover,the proportion of patients with adverse effects in the ALA-PDT group (3.57%) was also significantly lower than that in the control group (88.24%,P0.01). The side-effects in patients treated with ALA-PDT mainly included mild burning and/or stinging restricted to the illuminated area while the control group showed such side effects as ulcer,ache and scar formation.Conclusion The present study shows that topical application of ALA-PDT is a simpler,more effective and safer therapy with a lower recurrence for the treatment of condyloma acuminatum in urethral orifice compared with conventional CO2 laser therapy.