INVESTIGATIONS OF THE CHANGE OF THE DNA CONTENT IN THE BONE MARROW OF GUINEA PIGS AND RATS FOLLOWIGN IRRADIATION

From the radioinduced reduction of the DNA content in the bone marrow of guinea pigs and rats the dependence on radiation dose and time was investigated. The radiation response in the bone marrow of rats appeared earlier than in the bone marrow of guinea pigs. Following whole-body irradiation with 25 r significant differences from the normal value did not appear on one of the days fixed for investigation after irradiation in the bone marrow of either species. The reductions of DNA, which appeared on the first day after irradiation following the application of 50 r, were plotted and tabulated for radiation doses of 50, 100, ation. The significance of differences between radiation effects of the same radiation doses on different days and radiation effects of different radiation doses on the same days is emphasized. (auth)