ScholarLens Back to search
2010•Asian Journal of Research in ChemistryRequires access

RP-HPLC Determination of Amlodipine from Tablet Dosage Forms

Ravinder Burugu

Open publisher page 2 citations

Abstract

A simple, specific, accurate and precise high performance liquid chromatographic method was developed for the determination of Amlodipine in Amlodipine besylate tablet dosage forms. A Hypersil BDS C8 5μm (250x4.6mm I.D) with column temperature 25°C in isocratic mode, with mobile phase containing Acetonitrile: 10mM KH2PO4 buffer pH 3.0 (35:65) was used. The flow rate was 1.5mL/min and effluent was monitored at 237nm. The retention time of Amlodipine was 6.5min. The linearity for Amlodipine was in the range 0.02mg/mL to 0.12mg/mL. The proposed method is accurate, precise, specific and rapid estimation of Amlodipine in Amlodipine besilate tablets.

About this research paper

What this paper is about

A simple, specific, accurate and precise high performance liquid chromatographic method was developed for the determination of Amlodipine in Amlodipine besylate tablet dosage forms. A Hypersil BDS C8 5μm (250x4.6mm I.D) with column temperature 25°C in isocratic mode, with mobile phase containing Acetonitrile: 10mM KH2PO4 buffer pH 3.0 (35:65) was used. The flow rate was 1.5mL/min and effluent was monitored at 237nm. The retention time of Amlodipine was 6.5min. The linearity for Amlodipine was in the range 0.02mg/mL to 0.12mg/mL. The proposed method is accurate, precise, specific and rapid estimation of Amlodipine in Amlodipine besilate tablets.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

A simple, specific, accurate and precise high performance liquid chromatographic method was developed for the determination of Amlodipine in Amlodipine besylate tablet dosage forms. A Hypersil BDS C8 5μm (250x4.6mm I.D) with column temperature 25°C in isocratic mode, with mobile phase containing Acetonitrile: 10mM KH2PO4 buffer pH 3.0 (35:65) was used. The flow rate was 1.5mL/min and effluent was monitored at 237nm. The retention time of Amlodipine was 6.5min. The linearity for Amlodipine was in the range 0.02mg/mL to 0.12mg/mL. The proposed method is accurate, precise, specific and rapid estimation of Amlodipine in Amlodipine besilate tablets.

Key concepts: Amlodipine, Chromatography, Dosage form, Retention time, Chemistry, Phosphate buffered saline, High-performance liquid chromatography, Acetonitrile

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
RP-HPLC Determination of Amlodipine from Tablet Dosage Forms — Research Paper | ScholarLens