2004•PubMedRequires access

Role of fibrinolysis in tissue-factor-induced disseminated intravascular coagulation in rats - an effect of tranexamic acid.

Hidesaku Asakura, Yoko Sano, Masahide Yamazaki, Eriko Morishita, Ken‐ichi Miyamoto, Shinji Nakao

Abstract

We clarified the role of fibrinolysis in tissue-factor (TF)-induced rat disseminated intravascular coagulation (DIC) using tranexamic acid (TA). TA suppressed the elevation in D-dimer levels normally observed following TF-induced DIC, and an increase in organ dysfunction was seen. Enhanced fibrinolysis plays an important role in preventing the development of organ failure in TF-induced DIC.

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Key concepts: Fibrinolysis, Tranexamic acid, Disseminated intravascular coagulation, Tissue factor, Coagulation, Medicine, D-dimer, Internal medicine