Visible Spectrophotometric Determination of Amlodipine Besylate in Bulk Drug and Tablet Dosage Form

A simple visible spectrophotometric method has been developed for the estimation of amlodipine besylate in bulk and tablet dosage form. This method is based on the reaction between amlodipine besylate and potassium hydroxide in presence of dimethyl sulphoxide. The yellow chromogen obtained has absorbance maxima at 456nm. It obeys Beer's law in the concentration range of 3–30 mcg/ml. This method was validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the method is reproducible and selective for the estimation of said drug.