ScholarLens Back to search
2009•Zhongguo yufang shouyi xuebaoRequires access

Valuation of protective efficacy of PRRS attenuated vaccine and inactivated mutant PRRSV strains.

Shouping Hu, Zhuo Zhang, Cai XueHui, Tian ZhiJun, Yonggong Liu, An TongQing, Donglai Wu

Open publisher page 8 citations

Abstract

In this study,healthy piglets were immunized with porcine reproductive and respiratory syndrome(PRRS) CH-1R attenuated vaccine and inactivated PRRS vaccine,respectively,and challenged with PRRS virus(PRRSV) HuN-4 virulent strains 4 weeks after vaccination.All piglets were slaughtered on 21 day post-inoculation and tissue samples from main organs collected for H.E and immunohistochemistry staining to identify the distribution of the virus antigen.The results showed that the pathological change and the virus antigen distribution of the group immunized with inactivated vaccine were significantly higher than those of the group immunized with attenuated vaccine.Immunopathology studies indicated the immune protection of CH-1R attenuated vaccine was better than inactivated vaccine.

About this research paper

What this paper is about

In this study,healthy piglets were immunized with porcine reproductive and respiratory syndrome(PRRS) CH-1R attenuated vaccine and inactivated PRRS vaccine,respectively,and challenged with PRRS virus(PRRSV) HuN-4 virulent strains 4 weeks after vaccination.All piglets were slaughtered on 21 day post-inoculation and tissue samples from main organs collected for H.E and immunohistochemistry staining to identify the distribution of the virus antigen.The results showed that the pathological change and the virus antigen distribution of the group immunized with inactivated vaccine were significantly higher than those of the group immunized with attenuated vaccine.Immunopathology studies indicated the immune protection of CH-1R attenuated vaccine was better than inactivated vaccine.

Why it matters

OpenAlex reports 8 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

In this study,healthy piglets were immunized with porcine reproductive and respiratory syndrome(PRRS) CH-1R attenuated vaccine and inactivated PRRS vaccine,respectively,and challenged with PRRS virus(PRRSV) HuN-4 virulent strains 4 weeks after vaccination.All piglets were slaughtered on 21 day post-inoculation and tissue samples from main organs collected for H.E and immunohistochemistry staining to identify the distribution of the virus antigen.The results showed that the pathological change and the virus antigen distribution of the group immunized with inactivated vaccine were significantly higher than those of the group immunized with attenuated vaccine.Immunopathology studies indicated the immune protection of CH-1R attenuated vaccine was better than inactivated vaccine.

Key concepts: Inactivated vaccine, Virology, Biology, Attenuated vaccine, Vaccination, Virus, Antigen, Immune system

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Valuation of protective efficacy of PRRS attenuated vaccine and inactivated mutant PRRSV strains. — Research Paper | ScholarLens