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Intracavernous Injection of Vasoactive Drugs for the Treatment of Impotence

Samuel Man-Chung Lui, Johnny Shinn-Nan Lin

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Abstract

In a prospective study of 119 consecutive impotent patients, we evaluated the efficacy and safety of intracavernous injection of various vasoactive agents. Of the 119 patients, 34 (79.1%) achieved a full erection out of the 43 patients in Prostaglandin E (PGE) group, whereas only 51 (67.1%) achieved a full erection out of 76 patients in Papaverine (PA) plus Phentolamine, was the most significant complication and only occurred in 4 (5.3%) Regitine (RE) group. Priapism was the most significa complication and only occurred in 4 (5.3%) in PA+RE group. In conclusion, intracavernous injection of PGE appear to be better efficiency (at significant level α=0.2, P value=0.16) and less complication than PA+RE. However, the long-term effects must be determined.

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What this paper is about

In a prospective study of 119 consecutive impotent patients, we evaluated the efficacy and safety of intracavernous injection of various vasoactive agents. Of the 119 patients, 34 (79.1%) achieved a full erection out of the 43 patients in Prostaglandin E (PGE) group, whereas only 51 (67.1%) achieved a full erection out of 76 patients in Papaverine (PA) plus Phentolamine, was the most significant complication and only occurred in 4 (5.3%) Regitine (RE) group. Priapism was the most significa complication and only occurred in 4 (5.3%) in PA+RE group. In conclusion, intracavernous injection of PGE appear to be better efficiency (at significant level α=0.2, P value=0.16) and less complication than PA+RE. However, the long-term effects must be determined.

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Available abstract

In a prospective study of 119 consecutive impotent patients, we evaluated the efficacy and safety of intracavernous injection of various vasoactive agents. Of the 119 patients, 34 (79.1%) achieved a full erection out of the 43 patients in Prostaglandin E (PGE) group, whereas only 51 (67.1%) achieved a full erection out of 76 patients in Papaverine (PA) plus Phentolamine, was the most significant complication and only occurred in 4 (5.3%) Regitine (RE) group. Priapism was the most significa complication and only occurred in 4 (5.3%) in PA+RE group. In conclusion, intracavernous injection of PGE appear to be better efficiency (at significant level α=0.2, P value=0.16) and less complication than PA+RE. However, the long-term effects must be determined.

Key concepts: Vasoactive, Papaverine, Medicine, Intracavernous injection, Phentolamine, Priapism, Complication, Prostaglandin E1

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