Protection of mice immunized with recombinant P53 protein against Trichinella spiralis.

To evaluate the immunoprotection of Trichinella spiralis recombinant P53 protein, the mice were immunized with a dose of 50 μg/100 μL of P53 recombinant protein for three immunizations at ten-days intervals. Each mouse was challenged with 200 muscle larvae of T. spiralis 10 days post the final immunization. Adult worms and newborn larvae producted were detected at 7 days and muscle larvae at 35 days post challenge, respectively. The results showed that the reduction rates of adult worms, newborn larvae and muscle larvae were 61.9 %, 53.45 % and 71.48 %, respectively. The P53 recombinant protein could induce immunoprotection in mice against T. spiralis.