Simultaneous Estimation of Ranitidine and Drotaverine in Combined Pharmaceutical Dosage Form by Derivative Spectrophotometric Method

A Derivative Spectrophotometric method has been developed for simultaneous estimation of Ranitidine and Drotaverine in combined Pharmaceutical dosage forms. Methanol was used as solvent. The method involves the measurement of absorbance at two wavelength 322 nm (λmax for Ranitidine) and 306.5 nm (λmax for Drotaverine). The linearity lies between 5–60μg/ml for Ranitidine and 4–20μg/ml for Drotaverine. The accuracy and precision of methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2.The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Ranitidine and Drotaverine in combined pharmaceutical dosage form.