2014•Asian Journal of Pharmaceutical AnalysisRequires access
Simultaneous Estimation of Drotaverine HCl and Nimesulide in a Tablet Formulation by Absorbance Ratio Method
Ashok P. Pingale, Ambadas Ranganath Rote, Ravindranath Bhanudas Saudagar, Rima Ramesh Patil, Ghanshyam B. Jadhav
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Abstract
Spectrophotometric method were proposed for the simultaneous analysis of Drotaverine HCl and Nimesulide in a tablet formulationby absorbance ratio method at 278 nm (isoabsorptive point) and 304 nm(λ max of Drotaverine HCl) with mean percentage recovery 98.25%±0.66 and 100.5%±0.95, respectively. Beer's law for both methods was obeyed in the concentration range 5–25μg/ml of drotaverine HCl and Nimesulide respectively. The suggested method were successfully applied for the analysis of the two drugs in their pharmaceutical formulation. The obtained results were statistically agreed with those obtained by the reported method.