In vitro Antagonistic Activity of Candida albicans against Filamentous Fungi

Background: Candida albicans is a special type of yeast that is naturally found on the surface of various mucosal layers of the human body. Biofilms forming is well known synergistic relationship between C. albicans and various organisms with no or little aggressive acted toward each other. Methods and findings: C. albicans that isolated from patient with cutaneous candidiasis was tested for antifungal activity against six species of filamentous fungi by measuring of percentage inhibition. The effects of incubation periods and different concentrations of glucose on the antifungal activity of C. albicans were also tested. The percentage inhibition of growing filamentous fungi had been observed at high values when they cultivated on media that previously cultured with C. albicans than when both of fungi and C. albicans cultured at the same time, especially at low concentrations of glucose. Mucor spp. and C. sitophila had been affected by C. albicans only when they cultivated on media that previously cultured with C. albicans. Conclusion: C. albicans had been shown the ability to inhibit various species of filamentous fungi. Incubation periods and glucose concentrations had been effected on the inhibitory action of C. albicans against other fungi.