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2013•Research Journal of Pharmacology and PharmacodynamicsRequires access

In-vitro Antioxidant activity of Premna integrifolia Linn. Roots

Sanjay Jain, Mamta Singh, Rakesh Kumar Barik, Neelesh Malviya

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Abstract

Free radicals are fairly unstable and highly reactive substances, causing oxidation and sometimes irreversible damage to cells. This has led to an increase in intake of antioxidants. Medicinal plants are being studied extensively for their antioxidant properties. The present study was aimed to study the in-vitro antioxidant activity of aqueous and methanolic extracts of Premna integrifolia Linn roots (Verbenaceae). Both the extracts were subjected to various in-vitro antioxidant activity screening models such as DPPH, DMSO, ABTS, Nitric oxide and Iron chelation assay. Ascorbic acid was used as the standard. In all the models studied, the aqueous extract showed IC50 values of 111.009, 101.369, 99.976, 109.827, 105.239 μg/ml and the methanolic extract showed IC50 values of 98.252, 96.559, 88.163, 100.631, 95.005μg/ml for DPPH, DMSO, ABTS, Nitric oxide and Iron chelation assay, respectively.

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What this paper is about

Free radicals are fairly unstable and highly reactive substances, causing oxidation and sometimes irreversible damage to cells. This has led to an increase in intake of antioxidants. Medicinal plants are being studied extensively for their antioxidant properties. The present study was aimed to study the in-vitro antioxidant activity of aqueous and methanolic extracts of Premna integrifolia Linn roots (Verbenaceae). Both the extracts were subjected to various in-vitro antioxidant activity screening models such as DPPH, DMSO, ABTS, Nitric oxide and Iron chelation assay. Ascorbic acid was used as the standard. In all the models studied, the aqueous extract showed IC50 values of 111.009, 101.369, 99.976, 109.827, 105.239 μg/ml and the methanolic extract showed IC50 values of 98.252, 96.559, 88.163, 100.631, 95.005μg/ml for DPPH, DMSO, ABTS, Nitric oxide and Iron chelation assay, respectively.

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Available abstract

Free radicals are fairly unstable and highly reactive substances, causing oxidation and sometimes irreversible damage to cells. This has led to an increase in intake of antioxidants. Medicinal plants are being studied extensively for their antioxidant properties. The present study was aimed to study the in-vitro antioxidant activity of aqueous and methanolic extracts of Premna integrifolia Linn roots (Verbenaceae). Both the extracts were subjected to various in-vitro antioxidant activity screening models such as DPPH, DMSO, ABTS, Nitric oxide and Iron chelation assay. Ascorbic acid was used as the standard. In all the models studied, the aqueous extract showed IC50 values of 111.009, 101.369, 99.976, 109.827, 105.239 μg/ml and the methanolic extract showed IC50 values of 98.252, 96.559, 88.163, 100.631, 95.005μg/ml for DPPH, DMSO, ABTS, Nitric oxide and Iron chelation assay, respectively.

Key concepts: DPPH, ABTS, Antioxidant, Ascorbic acid, Traditional medicine, Chemistry, Verbenaceae, Nitric oxide

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