2009•Zhongguo xin yao zazhiRequires access
A selective cooxygenase-2 inhibitor for injection: parecoxib sodium
Xiangli Cui, Zhao Zhigang, Chen Li, Ming Li, Tiantan Hospitalaffiliatedtocapitalmedicaluniversity, Beijing Beijing
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Abstract
parecoxib sodium,the first injection preparation of selective cyclooxygenase-2 inhibitors,is used as an analgesic for acute postoperative pain.Its efficacy has been proved in the stomatologic,gynecologic,or orthopedic surgery.Intravenous paricoxib 40 mg,twice a day,can also reduce the morphine consumption and improve postoperative analgesia.In this review,we summarized the pharmacological mechanism,clinical research and safety of parecoxib.