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2010•Research Journal of Pharmacy and TechnologyRequires access

HPTLC Method for the Simultaneous Estimation of Aceclofenac and Diacerein in Tablets Dosage Forms

R Siva Kumar, N Srisutherson, P. Kumar Nallasivan, P. Arulraj, R. Venkatnarayanan

Open publisher page 2 citations

Abstract

A new simple, accurate, precise HPTLC method has been developed for the simultaneous estimation of Aceclofenac and Diacerein in tablets formulation. In this method standard and sample solutions of Aceclofenac and Diacerein were applied on pre-coated silica gel G 60 f 254 TLC plate, and developed using chloroform: methanol (8: 2 v/v), as mobile phase. The drugs on plate were scanned at 256nm. The dynamic linearity range was 10–50 μg/spot for aceclofenac and 5–25 μg/spot for Diacerein. The method was validated for precision, accuracy and reproducibility.

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What this paper is about

A new simple, accurate, precise HPTLC method has been developed for the simultaneous estimation of Aceclofenac and Diacerein in tablets formulation. In this method standard and sample solutions of Aceclofenac and Diacerein were applied on pre-coated silica gel G 60 f 254 TLC plate, and developed using chloroform: methanol (8: 2 v/v), as mobile phase. The drugs on plate were scanned at 256nm. The dynamic linearity range was 10–50 μg/spot for aceclofenac and 5–25 μg/spot for Diacerein. The method was validated for precision, accuracy and reproducibility.

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Available abstract

A new simple, accurate, precise HPTLC method has been developed for the simultaneous estimation of Aceclofenac and Diacerein in tablets formulation. In this method standard and sample solutions of Aceclofenac and Diacerein were applied on pre-coated silica gel G 60 f 254 TLC plate, and developed using chloroform: methanol (8: 2 v/v), as mobile phase. The drugs on plate were scanned at 256nm. The dynamic linearity range was 10–50 μg/spot for aceclofenac and 5–25 μg/spot for Diacerein. The method was validated for precision, accuracy and reproducibility.

Key concepts: Aceclofenac, Dosage form, Reproducibility, Chromatography, Mathematics, Chemistry

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