Significance of oxidative stress changes in type 2 diabetic patients after gastric bypass

Objective To observe the changes in oxidative stress in type 2 diabetic(T2DM) patients after gastric bypass,and investigate the mechanism of gastric bypass treatment for T2DM.Methods Thirty T2DM patients who underwent gastric bypass(T2DM group) and thirty healthy subjects(control group) were included in present study from Aug.2009 to Apr.2010.Values of fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2hPG),glycosylated hemoglobin(HbA1c),fasting plasma insulin(FIns),superoxide dismutase(SOD),malondialdehyde(MDA) and glutathione peroxidase(GSH-PX) were determined in T2DM group before surgery and 1,3,6 months after surgery.All the parameters were determined once in control group.Results Compared with control group,MDA was significantly higher(3.6±1.3 vs 2.2±0.7μmol/L,P < 0.01),and SOD and GSH-PX were significantly lower(45.2±18.8 vs 87.6±20.4kU/L,P < 0.01;53.6±16.8 vs 78.9±15.6mmol/L,P < 0.01) in T2DM group.Compared with the preoperative values,the MDA decreased significantly(P < 0.05),and SOD and GSH-PX increased significantly(P < 0.01) in T2DM group 3 months after operation.Compared with preoperative values,FPG,2hPG and HbA1c decreased significantly(P < 0.01) in T2DM group one month after operation.Compared with the values one month after operation,2hPG and HbA1c decreased significantly(P < 0.01,P < 0.05) 3 months after operation.Values of HOMA-IR decreased significantly from one month to six months after surgery(P < 0.01).Conclusions Oxidative stress can be improved markedly after gastric bypass in T2DM patients.It may be one of the mechanisms of suceessful treatment of T2DM with gastric bypass.