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2010•Asian Journal of Research in ChemistryRequires access

Simultaneous RP-HPLC Determination of Drotaverine Hydrochloride and Mefenamic Acid in Their Combined Tablet Dosage Form

Ram Suresh Sakhare, A. B. Roge, Ravindra L. Bakal, A. Dewani, M. D. Kshirsagar, Anil Vishwanath Chandewar

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Abstract

A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure was developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in tablet dosage form at a single wavelength. The mobile phase used was a combination of Methanol: Acetonitrile: KH2PO4 Buffer (10 mM): (40: 40: 20) pH 3.5. The detection of the combined dosage form was carried out at 240 nm and flow rate was set to 1ml/min. Linearity was obtained in the concentration range of 3 to 30 μg/ml of Drotaverine HCL and 6 to 33 μg/ml of Mefenamic Acid with correlation coefficients of 0.9998 and 0.9999, respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.

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What this paper is about

A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure was developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in tablet dosage form at a single wavelength. The mobile phase used was a combination of Methanol: Acetonitrile: KH2PO4 Buffer (10 mM): (40: 40: 20) pH 3.5. The detection of the combined dosage form was carried out at 240 nm and flow rate was set to 1ml/min. Linearity was obtained in the concentration range of 3 to 30 μg/ml of Drotaverine HCL and 6 to 33 μg/ml of Mefenamic Acid with correlation coefficients of 0.9998 and 0.9999, respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.

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Available abstract

A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure was developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in tablet dosage form at a single wavelength. The mobile phase used was a combination of Methanol: Acetonitrile: KH2PO4 Buffer (10 mM): (40: 40: 20) pH 3.5. The detection of the combined dosage form was carried out at 240 nm and flow rate was set to 1ml/min. Linearity was obtained in the concentration range of 3 to 30 μg/ml of Drotaverine HCL and 6 to 33 μg/ml of Mefenamic Acid with correlation coefficients of 0.9998 and 0.9999, respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.

Key concepts: Mefenamic acid, Chromatography, Dosage form, Chemistry, High-performance liquid chromatography, Acetonitrile

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Simultaneous RP-HPLC Determination of Drotaverine Hydrochloride and Mefenamic Acid in Their Combined Tablet Dosage Form — Research Paper | ScholarLens