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2006•Unpublished venueRequires access

Cytotoxic Effect of Hexavalent Chromium on C6 Glioma Cells

Seung‐Han Suk

Open publisher page 7 citations

Abstract

Toxic effect of Hexavalent chromium (CrO 3 ) on various cells and organs has been well recognized. However, the mechanism and degree of cytotoxicity of CrO 3 remain unclear. This study was performed to examine the cytotoxicity of CrO 3 on C6 glioma cells by measuring cell viability. The XTT assay, one of the sensitive methods to determine the cell viability, was taken to examine the viability of glioma cells treated with CrO 3 . In this study, not only decreased the number of glioma cells but morphologic changes of them were noted and cell viability decreased in a time and dose-dependent manner after treated with various concentrations of CrO 3 for 48 hours. IC 90 and IC 50 values in XTT assay were determined at 25 μM and 55 μM CrO 3 , respectively. These results suggest that Hexavalent chromium has a highly cytotoxic effect and has a time and dose-dependent cytotoxicity on C 6 glioma cells.

About this research paper

What this paper is about

Toxic effect of Hexavalent chromium (CrO 3 ) on various cells and organs has been well recognized. However, the mechanism and degree of cytotoxicity of CrO 3 remain unclear. This study was performed to examine the cytotoxicity of CrO 3 on C6 glioma cells by measuring cell viability. The XTT assay, one of the sensitive methods to determine the cell viability, was taken to examine the viability of glioma cells treated with CrO 3 . In this study, not only decreased the number of glioma cells but morphologic changes of them were noted and cell viability decreased in a time and dose-dependent manner after treated with various concentrations of CrO 3 for 48 hours. IC 90 and IC 50 values in XTT assay were determined at 25 μM and 55 μM CrO 3 , respectively. These results suggest that Hexavalent chromium has a highly cytotoxic effect and has a time and dose-dependent cytotoxicity on C 6 glioma cells.

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Available abstract

Toxic effect of Hexavalent chromium (CrO 3 ) on various cells and organs has been well recognized. However, the mechanism and degree of cytotoxicity of CrO 3 remain unclear. This study was performed to examine the cytotoxicity of CrO 3 on C6 glioma cells by measuring cell viability. The XTT assay, one of the sensitive methods to determine the cell viability, was taken to examine the viability of glioma cells treated with CrO 3 . In this study, not only decreased the number of glioma cells but morphologic changes of them were noted and cell viability decreased in a time and dose-dependent manner after treated with various concentrations of CrO 3 for 48 hours. IC 90 and IC 50 values in XTT assay were determined at 25 μM and 55 μM CrO 3 , respectively. These results suggest that Hexavalent chromium has a highly cytotoxic effect and has a time and dose-dependent cytotoxicity on C 6 glioma cells.

Key concepts: Cytotoxicity, Hexavalent chromium, Cytotoxic T cell, Glioma, Viability assay, Molecular biology, Chemistry, Chromium

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