2005•Iranian journal of pharmacology & therapeuticsRequires access

Anti-Hepatitis B Virus Activity of Flavonoids from Marchantia Convoluta

Jianbo Xiao, Ren Feng-lian, Ming Xu

Abstract

Flavonoids from Marchantia convoluta (MCF) were studied for their ability to inhibit the proliferation of 2.2.15 cells. All concentration of MCF inhibited the secretion of HBsAg and HBeAg in the cultured medium by 2.2.15 cells. Analysis of morphological changes of MCF-treated cells by phase-contrast microscopy revealed a possible mode of action for MCF: inhibition of proliferation of 2.2.15 cells by inducing apoptosis.

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Key concepts: Chemistry, HBsAg, HBeAg, Apoptosis, Phase contrast microscopy, Virus, Cell biology, Hepatitis B virus