2009•Research Journal of Pharmacy and TechnologyRequires access

Simultaneous Estimation of Ofloxacin and Satranidazole in Bulk and Dosage form by Ratio Spectra Derivative Spectroscopy

Shashikant R Pattan, Syed N Lateef, Prakash N. Kendre, Nachiket S Dighe, Rahul Keshav Godge

Abstract

A new sensitive, simple, rapid and precise method for simultaneous estimation of Ofloxacin and Satranidazole in bulk and combined tablet dosage form has been developed. The method is based on ratio derivative Spectrophotometry. The amplitude in first derivative of the ratio spectra at 300 nm and 222 nm (minima) were selected for Ofloxacin and Satranidazole respectively. The concentration range for Ofloxacin and Satranidazole chosen was 2–20 μg/ml and 3–30 μg/ml respectively. The method showed good linearity, accuracy and reproducibility. Results of analysis validated statistically and by recovery studies.

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Key concepts: Ofloxacin, Reproducibility, Derivative (finance), Dosage form, Second derivative, Chromatography, Spectrophotometry, Mathematics