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2002•Unpublished venueRequires access

EFFECT OF ESTROGEN REPLACEMENT THERAPY ON SERUM CYTOKINES (IL-1α, IL-6, TNF-α) IN OVARIECTOMIZED RATS

Mansur Rahnama, Tomasz Tomaszewski

Open publisher page 2 citations

Abstract

The aim of this study was to examine the changes in serum cytokine levels (Il-1α, Il-6, TNF-α) in ovariectomized rats with and without replacement estrogen therapy. Female Wistar rats were used. Rats were qualified for the following groups: Cl - control, SH - sham-operated, OV - after ovariectomy, OVH - after ovariectomy receiving 17 β-estradiol in three different doses (1.25, 12.5, 125 μg) during seven weeks. After ovariectomy the level of each examined cytokine was significantly increased. After the administration of three different doses of 17 β-estradiol the concentration of the examined cytokines was reduced in different degree.

About this research paper

What this paper is about

The aim of this study was to examine the changes in serum cytokine levels (Il-1α, Il-6, TNF-α) in ovariectomized rats with and without replacement estrogen therapy. Female Wistar rats were used. Rats were qualified for the following groups: Cl - control, SH - sham-operated, OV - after ovariectomy, OVH - after ovariectomy receiving 17 β-estradiol in three different doses (1.25, 12.5, 125 μg) during seven weeks. After ovariectomy the level of each examined cytokine was significantly increased. After the administration of three different doses of 17 β-estradiol the concentration of the examined cytokines was reduced in different degree.

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Available abstract

The aim of this study was to examine the changes in serum cytokine levels (Il-1α, Il-6, TNF-α) in ovariectomized rats with and without replacement estrogen therapy. Female Wistar rats were used. Rats were qualified for the following groups: Cl - control, SH - sham-operated, OV - after ovariectomy, OVH - after ovariectomy receiving 17 β-estradiol in three different doses (1.25, 12.5, 125 μg) during seven weeks. After ovariectomy the level of each examined cytokine was significantly increased. After the administration of three different doses of 17 β-estradiol the concentration of the examined cytokines was reduced in different degree.

Key concepts: Ovariectomized rat, Internal medicine, Estrogen, Cytokine, Endocrinology, Medicine, Tumor necrosis factor alpha, Estrogen replacement therapy

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EFFECT OF ESTROGEN REPLACEMENT THERAPY ON SERUM CYTOKINES (IL-1α, IL-6, TNF-α) IN OVARIECTOMIZED RATS — Research Paper | ScholarLens