Synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted-1H-imidazole derivatives and or 2,4,5-Triaryloxazoles using of Silica-Supported Preyssler Nanoparticles

One-pot multi-component condensation of benzil and or benzoin, aldehydes, ammonium acetate and primary amines were used for synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted-1H-imidazole derivatives under reflux conditions using Silica-supported Preyssler nanoparticles heteropolyacid as a catalysts. This catalyst has several advantages (simple work-up, inexpensive and reusability). These catalysts were also successfully employed in the synthesis of triaryloxazoles.