2010•Journal of ChemistryOpen access

One‐Pot Synthesis of Tetrasubstituted Imidazoles Catalyzed by Preyssler‐Type Heteropoly Acid

Ali Javid, Majid Momahed Heravi, Fatemeh F. Bamoharram, Mohsen Nikpour

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Abstract

A simple one‐pot four‐component synthetic method was reported for the preparation of tetrasubstituted imidazole derivatives from benzil, aromatic aldehydes, primary amines and ammonium acetate in the presence of Preyssler‐type heteropoly acid catalyst. This method was proved to be eco‐benign, easy work‐up, convenient, relatively short reaction times and the products were isolated with high yields.

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A simple one‐pot four‐component synthetic method was reported for the preparation of tetrasubstituted imidazole derivatives from benzil, aromatic aldehydes, primary amines and ammonium acetate in the presence of Preyssler‐type heteropoly acid catalyst. This method was proved to be eco‐benign, easy work‐up, convenient, relatively short reaction times and the products were isolated with high yields.

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Available abstract

A simple one‐pot four‐component synthetic method was reported for the preparation of tetrasubstituted imidazole derivatives from benzil, aromatic aldehydes, primary amines and ammonium acetate in the presence of Preyssler‐type heteropoly acid catalyst. This method was proved to be eco‐benign, easy work‐up, convenient, relatively short reaction times and the products were isolated with high yields.

Key concepts: Heteropoly acid, Catalysis, Chemistry, Organic chemistry, Combinatorial chemistry

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