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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF GLICLAZIDE Research Article

N Jahnavi, Shri Vishnu

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Abstract

Gliclazide is a second generation sulfonyl urea derivative used to treat non insulin dependent diabetes mellitus. The drug has been classified as class-II drug according to biopharmaceutical classification system having low solubility and high permeability. So an attempt was made to enhance the solubility of gliclazide by solid dispersion technique. In this sodium starch glycolate, crospovidone were mixed with the drug in different ratios (1:1, 1:3, 1:5). The optimized solid dispersion was evaluated and formulated in to tablets. The pre and post compression parameters of the tablets were evaluated and compared with the marketed brands. The FTIR & XRD studies revealed that there is no interaction between the drug and excipients used in the formulation.

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What this paper is about

Gliclazide is a second generation sulfonyl urea derivative used to treat non insulin dependent diabetes mellitus. The drug has been classified as class-II drug according to biopharmaceutical classification system having low solubility and high permeability. So an attempt was made to enhance the solubility of gliclazide by solid dispersion technique. In this sodium starch glycolate, crospovidone were mixed with the drug in different ratios (1:1, 1:3, 1:5). The optimized solid dispersion was evaluated and formulated in to tablets. The pre and post compression parameters of the tablets were evaluated and compared with the marketed brands. The FTIR & XRD studies revealed that there is no interaction between the drug and excipients used in the formulation.

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Available abstract

Gliclazide is a second generation sulfonyl urea derivative used to treat non insulin dependent diabetes mellitus. The drug has been classified as class-II drug according to biopharmaceutical classification system having low solubility and high permeability. So an attempt was made to enhance the solubility of gliclazide by solid dispersion technique. In this sodium starch glycolate, crospovidone were mixed with the drug in different ratios (1:1, 1:3, 1:5). The optimized solid dispersion was evaluated and formulated in to tablets. The pre and post compression parameters of the tablets were evaluated and compared with the marketed brands. The FTIR & XRD studies revealed that there is no interaction between the drug and excipients used in the formulation.

Key concepts: Gliclazide, Solubility, Drug, Biopharmaceutical, Chemistry, Dissolution, Friability, Chromatography

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