FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES

Fast dissolving drug delivery systems offers a solution for paediatric, geriatric, mentally ill people and those patients having difficulty in swallowing tablets or capsules. In the present study, an attempt had been made to prepare fast dissolving tablets of Bisoprololfumarate, an antihypertensive agent. The fast dissolving tablets were prepared by direct compression method using sodium starch glycolate, Croscarmellose sodium and Crospovidone as super disintegrants in different conce ntration. Compatibility studies of excipients and drug were carried out using FT-IR spectroscopy. Formulations were evaluated for precompressional parameters such as density, angle of repose, Carr’s index and hausner’s ratio. The tablets were evaluated fo r weight variation, thickness, hardness, friability, drug content, wetting time, disintegration time and in-vitro dissolution study. No chemical interaction between drug and excipients was confirmed by FTIR studies. All the formulation showed satisfactory tablet properties. The formulation F9 contain (5 %) crospovidone showed maximum drug release