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COGNITIVE ENHANCING ACTIVITY OF DOCOSAHEXAENOIC ACID AND GAMMA-LINOLENIC ACID IN LEAD INDUCED AMNESIA

Veena Sharma, Sachdev Yadav

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Abstract

The purpose of this study was to characterize the putative cognitive enhancing activity of docosahexaenoic acid and gamma-linolenic acid in lead induced amnesia. PRO-PL dietary supplement containing docosahexaenoic acid and gamma-linolenic acid was administered to study cognitive enhancing activity using elevated-plus maze model and employing piracetam (200 mg/kg i.p.) as the standard drug. In the elevated–plus maze, there was significant increase in time spent and number of entries into the open arms at doses of 100 and 200 mg/kg. Dietary supplement containing docosahexaenoic acid and gamma-linolenic acid showed prominent cognitive enhancing activity in mice.

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What this paper is about

The purpose of this study was to characterize the putative cognitive enhancing activity of docosahexaenoic acid and gamma-linolenic acid in lead induced amnesia. PRO-PL dietary supplement containing docosahexaenoic acid and gamma-linolenic acid was administered to study cognitive enhancing activity using elevated-plus maze model and employing piracetam (200 mg/kg i.p.) as the standard drug. In the elevated–plus maze, there was significant increase in time spent and number of entries into the open arms at doses of 100 and 200 mg/kg. Dietary supplement containing docosahexaenoic acid and gamma-linolenic acid showed prominent cognitive enhancing activity in mice.

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Available abstract

The purpose of this study was to characterize the putative cognitive enhancing activity of docosahexaenoic acid and gamma-linolenic acid in lead induced amnesia. PRO-PL dietary supplement containing docosahexaenoic acid and gamma-linolenic acid was administered to study cognitive enhancing activity using elevated-plus maze model and employing piracetam (200 mg/kg i.p.) as the standard drug. In the elevated–plus maze, there was significant increase in time spent and number of entries into the open arms at doses of 100 and 200 mg/kg. Dietary supplement containing docosahexaenoic acid and gamma-linolenic acid showed prominent cognitive enhancing activity in mice.

Key concepts: Docosahexaenoic acid, Linolenic acid, Piracetam, Amnesia, gamma-Linolenic acid, Chemistry, Food science, Biochemistry

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COGNITIVE ENHANCING ACTIVITY OF DOCOSAHEXAENOIC ACID AND GAMMA-LINOLENIC ACID IN LEAD INDUCED AMNESIA — Research Paper | ScholarLens