EFFECTS OF MUCOADHESIVE POLYMERS COMBINATION ON THE PROPERTIES OF LISINPRIL BUCCAL TABLETS PREPARED BY WET GRANULATION METHOD

Objective: The objective of this study was to prepare and characterize buccoadhesive tablets of Lisinopril using different Mucoadhesive polymers such as HPMC K100M, CMC, Chitosan, and combination. Methods: Six tablet formulations were prepared by wet granulation method with varying concentrations of polymers using combination of two polymers in each formulation. The prepared tablets were evaluated for physicochemical parameters such as hardness, thickness, content uniformity, weight variation, surface pH, and swelling studies. The prepared tablets were also evaluated for bioadhesive strength and in vitro drug release. Results: In vitro bioadhesive strength and in vitro release studies showed that formulation (F6) containing HPMC K100M and CMC in the ratio of (4:1) showed good mucoadhesive strength and maximum drug release in 6 hrs. The in vitro release kinetics studies reveal that all formulations fit well with zero order kinetics followed by Korsmeyer-Peppas. Conclusion: From the results it can be concluded that the formula (F6) will be promising drug delivery in buccal cavity for the treatment of anti hypertension with high possibility of increase in bioavailability due to avoidance of first pass effect .