FORMULATION AND INVITRO EVALUATION OF BUCCAL TABLETS OF METOPROLOL TARTRATE

The aim of study was to prepare and characterize buccoadhesive tablets of Metoprolol tartrate using different Mucoadhesive polymers such as Carbopol 934, Sodium alginate and HPMC K4M in combination. Ten formulations were prepared with varying concentrations of polymers using combination of two polymers in each formulation. Formulations F1 to F5 were composed of Sodium alginate and HPMC K4M mixture in drug: polymer mixture ratios of 1:0.75 to 1:1.75 where as formulations F6 to F10 were composed of carbopol 934 and HPMC K4M mixture in same drug: polymer mixture ratios. The prepared tablets were evaluated for physicochemical parameters such as hardness, thickness uniformity, weight variation, surface pH, Ex‐vivo residence time and moisture absorption studies. The prepared tablets were also evaluated for bioadhesive strength and in vitro drug release. In vitro bioadhesive strength and in vitro release studies showed that formulation F8 containing 1:1.25 ratio of drug and polymer combination showed optimum bioadhesive and exhibited optimum drug release (77.33±0.23). FTIR results showed no evidence of interaction between the drug and polymers.