Effect of Fexofenadine on Dog's Heart Performance

3 Abstract: Antihistamines are H blocker which is used in human and veterinary medicine. In humans for 1 treatment of allergic signs such as pruritus and anaphylactic reactions. The aim of this study was to evaluate fexofenadine effect on dog's heart performance. In this study 12 dogs were selected and Divided randomly into two groups, control and fexofenadine groups. Fexofenadine was given at two dose levels (3 and 18 mg/kg b.wt.) fexofenadine at the dose of the 3 and 18 mg/kgBW were administrated. In this study, the results revealed that fexofenadine has dose-independent effect on heart performance. It can be concluded that that administration of H -blockers as anti-histamincs in patients with cardiovascular disorders must be limited and prevented of 1 long-term usage in the patients in this patients.