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SPECTROPHOTOMETRIC METHOD FOR DEGRADATION STUDY OF LEVOFLOXACIN

Kusuma Priya K, G Bharathi

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Abstract

Spectrophotometric method for degradation study of Levofloxacin was described. The ultra violet spectr um of acidic, basic and oxidative degraded product was fo und to substantial difference from pure drug. The e xtent of degradation can be calculated by comparing the decr ease in absorbance at selective wavelength. The UV spectrum of Levofloxacin showed maximum absorbance at 287nm. The solution in alkaline, acidic and oxidative condition showed a decrease in absorbance at 287nm. So the decrease in absorbance at 287nm was used as measure of extent of degradation in all the degradation conditions. The degradation in acidic condition was found to be more when compared to alkaline and oxidative conditions.

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What this paper is about

Spectrophotometric method for degradation study of Levofloxacin was described. The ultra violet spectr um of acidic, basic and oxidative degraded product was fo und to substantial difference from pure drug. The e xtent of degradation can be calculated by comparing the decr ease in absorbance at selective wavelength. The UV spectrum of Levofloxacin showed maximum absorbance at 287nm. The solution in alkaline, acidic and oxidative condition showed a decrease in absorbance at 287nm. So the decrease in absorbance at 287nm was used as measure of extent of degradation in all the degradation conditions. The degradation in acidic condition was found to be more when compared to alkaline and oxidative conditions.

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Available abstract

Spectrophotometric method for degradation study of Levofloxacin was described. The ultra violet spectr um of acidic, basic and oxidative degraded product was fo und to substantial difference from pure drug. The e xtent of degradation can be calculated by comparing the decr ease in absorbance at selective wavelength. The UV spectrum of Levofloxacin showed maximum absorbance at 287nm. The solution in alkaline, acidic and oxidative condition showed a decrease in absorbance at 287nm. So the decrease in absorbance at 287nm was used as measure of extent of degradation in all the degradation conditions. The degradation in acidic condition was found to be more when compared to alkaline and oxidative conditions.

Key concepts: Absorbance, Degradation (telecommunications), Chemistry, Chromatography, Levofloxacin, Oxidative phosphorylation, Ultra violet, Materials science

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