2013•Unpublished venueRequires access
SPECTROPHOTOMETRIC METHOD FOR DEGRADATION STUDY OF LAMIVUDINE
K Gouthami, Anusha Priyadarshini K, Nikhila Soundarya A, Pushpa Latha E
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Abstract
Spectrophotometric method for degradation study of Lamivudine was described. The ultra violet spectrum of acidic, basic and oxidative degraded product was found to substantial difference from pure drug. The extent of degradation can be calculated by comparing the decrease in absorbance at selective wavelength. The UV spectrum of Lamivudine showed maximum absorbance at 270nm. The solution in NaOH showed a decrease in absorbance at 270 nm. So the decrease in absorbance at 270nm was used as measure of extent of degradation in NaOH. In case of NaOH degradation also decrease of absorbance is seen due to degradation but in comparison to NaOH degradation is lesser. In the basic degradation study it was found that Lamivudine is more sensitive to alkaline hydrolysis.