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2014•International Journal of PharmacyRequires access

ANTIMICROBIAL AND ANTIINFLAMMATORY ACTIVITIES OF SOME NOVEL TRIAZOLOTHIADIAZOLES

J Subbarao, S. Vidhyadhara, Neeladri Srinivasulu

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Abstract

A novel series of 1,2,4-triazolo [ 3,4-b] [ 1,3,4 ] thiadiazoles were prepared by treating 4-amino -3-substituted -5- mercapto-1,2,4-triazoles with 2-amino-4-(substituted phenyl)-3-carboethoxy benzopyron. Their chemical structures were confirmed by means of spectral data IR, 1H NMR and Elemental analysis. All the synthesized compounds were screened for antimicrobial activity and anti-inflammatory activities. Some of the synthesized compounds have shown very good antimicrobial and anti-inflammatory activities.

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What this paper is about

A novel series of 1,2,4-triazolo [ 3,4-b] [ 1,3,4 ] thiadiazoles were prepared by treating 4-amino -3-substituted -5- mercapto-1,2,4-triazoles with 2-amino-4-(substituted phenyl)-3-carboethoxy benzopyron. Their chemical structures were confirmed by means of spectral data IR, 1H NMR and Elemental analysis. All the synthesized compounds were screened for antimicrobial activity and anti-inflammatory activities. Some of the synthesized compounds have shown very good antimicrobial and anti-inflammatory activities.

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Available abstract

A novel series of 1,2,4-triazolo [ 3,4-b] [ 1,3,4 ] thiadiazoles were prepared by treating 4-amino -3-substituted -5- mercapto-1,2,4-triazoles with 2-amino-4-(substituted phenyl)-3-carboethoxy benzopyron. Their chemical structures were confirmed by means of spectral data IR, 1H NMR and Elemental analysis. All the synthesized compounds were screened for antimicrobial activity and anti-inflammatory activities. Some of the synthesized compounds have shown very good antimicrobial and anti-inflammatory activities.

Key concepts: Antimicrobial, Thiadiazoles, Chemistry, Anti-inflammatory, Elemental analysis, Combinatorial chemistry, Proton NMR, Spectral analysis

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