2011•Unpublished venueRequires access
ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL QUINAZOLINONES
Hemant Panwar, Nidhi Chaudhary, Sachi Singh, Shishupal Singh, Ganga Nagar
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Abstract
A series of 3-Amantadinyl-2-[(4-amino-3-aryl-5-ylthio)-1,2,4-triazolo]methyl)quinazolin-4-one 5(a-i) were prepared by the reaction of 3-Amantadinyl-2-[(4-acetamido-3-aryl-5-ylthio)-1,2,4-triazolo]methyl)quinazolin-4-one 4(a-i) with various 3-aryl-4-acetamido-5-mercapto triazoles. The compounds 5(a-i) biologically evaluated for their antiinflammatory and antibacterial activities.Structures of the newly synthesized compounds were established on the basis of elemental and spectral (IR, 1 H-NMR and Mass) analysis. Furthermore the prepared pharmacophores have been investigated for their their antifungal, antibacterial, and anti-inflammatory activities. Compound 5h has shown most active anti-inflammatory and antifungal and antibacterial activities.